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MicroRNAs and their big therapeutic impacts: delivery strategies for cancer intervention

Environmental factors such as heavy metal toxicity [1012], sub-clinical viral infections [13] and gastro-intestinal pathology [14, 15], as well as endogenous toxins produced by metabolic processes [16], hormones (reviewed in [17]) and gastro-intestinal bacteria [18, 19] have also been suggested as playing a role in the aetiology of the disorder, although none of these have been thoroughly investigated

It usually occurs due to hormonal changes during pregnancy or due to use of oral contraceptives, or as a side effect of hormone replacement therapy

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It regulates the natural defense system and supports the liver and gallbladder in fat metabolism